S100s and HMGB1 Crosstalk in Pancreatic Cancer Tumors

Pancreatic cancer remains a disease that is very difficult to treat. S100 proteins are small calcium binding with diverse intra- and extracellular functions modulate different aspects of tumorigenesis, including tumor growth metastasis. High mobility group box 1 (HMGB1) protein multifaceted also actively influences the development progression tumors. In this study, we investigate possible correlations, at transcript level, between S100s HMGB1 in pancreatic cancer. For purpose, calculated Pearson’s correlations levels 13 cancer-related genes cDNA array containing 19 samples, 8 human cell lines. Statistically significant positive were found 5.5% (5 out 91) 37.4% (34 S100/S100 or S100/HMGB1 pairs cells tumors, respectively. Our data suggest many crosstalk tumors either other members family, HMGB1. These newly observed interdependencies may be used further characterization based on transcription profiles.